Nom : PELHATE

Prénom : Marcel

Enseignant-chercheur : [X] HDR [X]

Chercheur [] HDR [X]

Date de naissance : 18/07/1938

1996

STANKIEWICZ M., PELHATE M., PANCERZYNSKA I., ZIENKIEWICZ A. & KADZIELA W.

Effect of K+ accumulation removal and high extracellular osmolality on K+ current in insect axonal membrane. Acta Neurobiol. Exp., 56 : 95-102.

1996

STANKIEWICZ M., BEN KHALIFA R., GROLLEAU F., TOMASZEWSKI R., KADZIELA W. & PELHATE M.

Late sodium induced by scorpion toxins and pyrethroid insecticides in insect neuronal membrane. Stud. Soc. Scient. Physiol., Torun, 4 : 93-102.

1996

SINAKEVITCH I., GEFFARD M., PELHATE M. & LAPIED B.

Anatomy and targets of dorsal unpaired median neurones in the terminal abdominal ganglion of the male cockroach Periplaneta americana L. J. Comp. Neurol., 367 : 147-163.

1996

STANKIEWICZ M., GROLLEAU F., LAPIED B., BORCHANI L., EL AYEB M. & PELHATE M.

Bot IT2, a toxin paralytic to insects from the Buthus occitanus tunetanus venom modifying the activity of insect sodium channels. J. Insect Physiol., 42 : 397-405.

1996

GORDON D., MARTIN-EAUCLAIRE M.F., CESTELE S., KOPEYAN C., CARLIER E., BEN KHALIFA R., PELHATE M. & ROCHAT H.

Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels. J. Biol. Chem., 271 : 8034-8045.

1996

BOUHAOUALA-ZAHAR B., DUCANCEL F., ZENOUAKI I., BEN KHALIFA R., BORCHANI L., PELHATE M., BOULAIN J.C., EL AYEB M., MENEZ A. & KAROUI H.

A novel recombinant insect specific alpha toxin of Buthus occitanus tunetanus scorpion confers protection against homologous mammal toxins. Europ. J .Biochem., 238 : 653-660.

1996

ZILBERBERG N., GORDON D., ZLOTKIN E., PELHATE M., ADAMS M.E., NORRIS T. & GUREVITZ M.

Functional expression and genetic modification of an alpha scorpion neurotoxin. Biochemistry , 35 : 10215-10222.

1996

BORCHANI L., MANSUELLE P., STANKIEWICZ M., GROLLEAU F., CESTELLE S., KAROUI H., LAPIED B., ROCHAT H., PELHATE M. & EL AYEB M.

A new scorpion venom toxin paralytic to insects that affects Na+ channel activation: Purification, structure antigenicity and mode of action. Eur. J. Biochem., 241 : 525-532.

1996

SHICHOR I., FAINZILBER M., PELHATE M., MALECOT C.O., ZLOTKIN E. & GORDON D.

Interactions of d-conotoxins with alkaloid neurotoxins reveal differences between the silent and effective binding sites on voltage-sensitive sodium channels J. Neurochem., 67 : 2451-2460.

1997

BORCHANI L., STANKIEWICZ., KOPEYAN C., MANSUELLE P., KHARRAT R., CESTELLE S., KAROUI H., ROCHAT H., PELHATE M. & EL AYEB M.

Purification, structure and activity of three insect toxins from the Buthus occitanus tunetanus venom. Toxicon , 35 : 365-382.

1997

TURKOV M., RASHI S., ZILBERBERG N., GORDON D., BEN KHALIFA R., STANKIEWICZ M., PELHATE M. & GUREVITZ M.

In vitro folding and fonctionnel analysis of an anti-insect selective scorpion depressant neurotoxin produced in Escherichia coli. Protein Express. Purific., 10, 123-131.

1997

BEN KHALIFA R., STANKIEWICZ M., PELHATE M., SERRANO-HERNANDEZ S.E., POSSANI L.D., HINKEL H. & MEBS D.

Action of Babycurus toxin 1 from the East-African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon. Toxicon, 35, 1069-1080.

1997

BEN KHALIFA R., STANKIEWICZ M., LAPIED B., TURKOV M., ZILBERBERG N., GUREVITZ M. & PELHATE M.

Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker. Life Sciences, 61, 819-830.

1998

PELHATE M., STANKIEWICZ M. & BEN KHALIFA R.

Les toxines anti-insectes de scorpions : historiques, modes d'action et perspectives. C. R . Soc. Biol., 192, 463-484

1998

GUREVITZ M., FROY O., ZILBERBERG N., TURKOV M., STRUGATZKY D., GERSHBURG E., ADAMS M.E., TUGARINOV V., ANGLISTER J., SHAANAN B., LORET E., STANKIEWICZ M., PELHATE M., GORDON D. & CHEJANOVSKY N.

Sodium channel modifiers from scorpion venom: Structure-activity relationship, mode of action, and application. Toxicon, 36, n°11, 1671-1682

1999

FROY O., ZILBERBERG N., GORDON D., TURKOV M., GILLES N., STANKIEWICZ M., PELHATE M., LORET E., OREN D., SHAANAN B. & GUREVITZ M.

The putative bioactive surface of insect-selective scorpion excitatory neurotoxins. J. Biol. Chem., 274, N° 9, 5769-5776.

1999

KRIMM I., GILLES N., SAUTIERE P., STANKIEWICZ M., PELHATE M., GORDON D & LANCELIN J.M.

NMR structures and activity of a novel alpha-like toxin, an acidic toxin from the scorpion Leiurus quinquestriatus hebraeus. J. Mol. Biol., 285, 1749-1764.

1999

CESTELE S., STANKIEWICZ M., MANSUELLE P., DE WAARD M., DARGENT B., GILLES N., PELHATE M., ROCHAT H., MARTIN-EAUCLAIRE M.F. & GORDON D.

Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects. Eur. J. Neurosciences., 11, 975-985.

1999

LAPIED B., STANKIEWICZ M., GROLLEAU F., ROCHAT H., ZLOTKIN E. & PELHATE M.

Biophysical properties of scorpion a-toxin-sensitive background sodium channel contributing to the pacemaker activity in insect neurosecretory cells (DUM neurons). Eur. J. Neuroscience, 11, 1449-1460.

1999

STANKIEWICZ M., HAMON A., BENKHALIFA R., KADZIELA W., HUE B., LUCAS S., MEBS D. & PELHATE M.

Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and an expressed Drosophila muscarinic receptor. Toxicon, 37, 1431-1445

1999

STANKIEWICZ M., GROLLEAU F., ROCHAT H., ZLOTKIN E., PELHATE M. & LAPIED B.

Insect background sodium channel as a new target for scorpion alpha toxin.
Pesticide Sciences, 1999, 55, 1021-1026.

1999

GEOFFRION R., STANKIEWICZ M., PELHATE M. & HUE B.

Les scorpions pourront-ils, un jour, être utiles pour la protection des
plantes?
Phytoma, n°520, Octobre 1999, 9-11.

2000

STANKIEWICZ M., PANEK I., GRAJPEL B., TEGOWSKA E., KADZIELA W. & PELHATE M.

Neurotoxin induced modification of a cockroach central nervous system bioelectrical activity. Postepy Higieny i Medycyny Doswiadczalnej = (Progress in Experimental Hygiene and Medicine ) , 2000, 54, 3, 371-379 – PL ISSN 0032-5449.

2000

CORZO G., ESCOUBAS P., STANKIEWICZ M.,PELHATE M., KRISTENSEN C.P. & NAKAJIMA T.

Isolation, synthesis and pharmacological characterization of novel insecticidal toxins from the spider Paracoelotes sp. (Agelenidae)
European J. Biochemistry, 267 (18) 5783-5795.

2000

ESCOUBAS P.,  STANKIEWICZ M. ,  TAKAOKA T., PELHATE M.,  ROMI-LEBRUN R., WU F.Q. & NAKAJIMA T.

Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensi.
FEBS Letters, 483 (2-3) 175-180.

2001

GROLLEAU F., STANKIEWICZ M., BIRINYI-STRACHAN L., WANG X.H., NICHOLSON G.M., PELHATE M.& LAPIED B.

Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.
J. Exp. Biol., 2001, 204 (4) 711-721.

2001

GROLLEAU F., GAMELIN L., BOISDRON-CELLE M., LAPIED B., PELHATE M. & GAMELIN E.

A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels.
J. Neurophysiol. 2001, 85, 2293-2297.

2002

De LIMA M.E., STANKIEWICZ M., HAMON A., De FIGUEIREDO S.G.,  CORDEIRO M.do N., DINIZ C.R., MARTIN-EAUCLAIRE M.F. &  PELHATE M.

The toxin Tx4(6-1) from the spider Phoneutria nigriventer slows
down Na+ current inactivation in insect CNS via binding to
receptor site 3.
Journal of Insect Physiology, Volume 48, Issue 1, Pages 53-61

2002

BOUHAOUALA-ZAHAR B., BENKHALIFA R., SRAIRI N., ZENOUAKI I., LIGNY-LEMAIRE C., DREVET P., SAMPIERI F., PELHATE M., EL AYEB M., MENEZ A., KAROUI H. & DUCANCEL F.

A chimeric scorpion alpha-insect toxin displays de novo electrophysiological properties similar to those of alpha-like toxins.
Europ. J. Biochemistry, 269, 2831-2841.

2002

MEJRI T., BORCHANI L., SRAIRI-ABID N., BENKHALIFA R., CESTELE S., REGAYA I., KAROUI H., PELHATE M., ROCHAT H., & EL AYEB M.

BotIT6 : a potent depressant insect toxin from Buthus occitanus tunetanus venom.
Toxicon, 41, 163-171.

2003

WANG C.G., LING M.H., CHI C.W., WANG D.C., STANKIEWICZ M. & PELHATE M.

Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch.
J. Peptide Research, 61, (1), 7-16.

2003

WANG CG, GILLES N. HAMON A., LE GALL F, STANKIEWICZ M, PELHATE M, XIONG YM, WANG DC, CHI CW

Exploration of the functional site of a scorpion a-like toxin by site-directed mutagenesis. Biochemistry. 2003, 42, 4699-4708

1994

ZLOTKIN E., MOSKOWITZ H., HERRMANN R., PELHATE M. & GORDON D.

The insect sodium channel as the target for insect selective neurotoxins from scorpion venom. In: Twelth School on Biophysics of Membrane Transport", School Proceedings, Zakopane, Poland, May 4-13, pp. 164-186.

1995

ZLOTKIN E., MOSKOWITZ H., HERRMANN R., PELHATE M. & GORDON D.

Insect Sodium Channel as the Target for Insect-Selective Neurotoxins from Scorpion Venom. From: "Molecular Action and Pharmacology of Insecticides on Ion Channels", 207th Amer. Chem. Soc. Nat. Meeting, San Diego, CA, 13-17/03/94. In "Molecular Action of Insecticides on Ion Channels" , J. Marshall Clarck ed., ACS Symp. Series n° 591, ACS , Washington, DC, Chap. 4, pp. 56-85.

1994

STANKIEWICZ M., PELHATE M. & KADZIELA W.

Extracellular K+ and neuronal activity. In : "Molecular and Physiological Aspects of Regulation in the Organisme", Ed. H. Lach, Krakov Symp. Acta, pp. 246-250.

1995

PANCERZYNSKA I., STANKIEWICZ M., PELHATE M., TOMASZEWSKI R., KADZIELA W. & ZIENKIEWICZ A.

Effects of periaxonal potassium accumulation removal on potassium current in a cockroach giant axon. In : "Molecular Aspects of Regulation in the Organism", Ed. H. Lach, pp. 255-257.

1995

STANKIEWICZ M., PELHATE M., BORCHANI L., ZIENKIEWICZ A., EL AYEB M. & KADZIELA W.

Modification of sodium channel activity in insect axonal membrane by scorpion toxins. In : "Molecular Aspects of Regulation in the Organism", Ed. H. Lach, pp. 297-299.

1996

STANKIEWICZ M., BEN KHALIFA R., GROLLEAU F., TOMASZEWSKI R., KADZIELA W. & PELHATE M.

Late sodium current induced by scorpion toxins and pyrethroid insecticides in insect neuronal membrane. In : "Physiology and Ecotoxicology of Insects and Mechanisms of Adaptation in Vertebrates", Stud. Soc. Scient. Physiol., Torun, Poland, n°3, 93-102.

1999

GUREVITZ M., FROY O., ZILBERBERG N., SHAANAN B., ADAMS M.E., ANGLISTER J., PELHATE M., CHEJANOVSKY N. and GORDON D.

Elucidation of the Bioactive Site and Potential Applications of Sodium Channel Modifiers from Scorpion Venom in : Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs, D.J. BEADLE, SCI, Oxford Brookes University, Oxford, UK, pp. 67-80.

2001

GRAJPEL B., KIELBASIEWICZ E., TEGOWSKA E., OLSZAK R., ROKICKI R., KADZIELA W., PELHATE M.& STANKIEWICZ M., 2001

Modification of a cockroach CNS neurone bioelectrical activity by oxadiazine insecticides. In « Molecular and Physiological Aspects of Regulatory Processes of the Organism ». pp 116-118, Henryk Lach editor, Cracow.

2001

STANKIEWICZ M., GROLLEAU F. & PELHATE M., 2001

Les alpha-toxines d’anémones et de scorpions sont actives même sans Na+ extracellulaire.  In « SFET Meeting Paris déc. 2001 Editions scientifiques et médicales Elsevier SAS, (in press).

2001

GROLLEAU F., STANKIEWICZ M., ESCOUBAS P., TOMALSKI M., PELHATE M. & LAPIED B.,

Unusual effects of arthropod neurotoxins on insect neuronal voltage-dependent calcium currents and calcium-sensitive chloride current.
In « Arthropods: Chemical, Physiological and Enviromental Aspects", Danuta Konopinska ed., Wydawnictwo Uniwersytetu Wroclawskiego, Wroclaw, 2002, pp. 59-65.

2002

GUREVITZ M., ZILBERBERG N., FROY O., TURKOV M., WILUNSKY R., KARBAT I., ANGLISTER J., SHAANAN B., PELHATE M., ADAMS M., GILLES N. & GORDON D.,

Diversification of toxic sites on a conserved protein scaffold – a scorpion recipe for survival. In "Perspectives in Molecular Toxinology ",  A. Menez  ed.., pp. 239-253, Wiley & Sons, Chichester, UK.

2002

KIELBASIEWICZ E., GROLLEAU F., STANKIEWICZ M., BERESS L. & PELHATE  M.

Efficacité conservée de deux toxines d'Anémone de mer chez l'insecte et le Mammifère. In "Toxines et Recherches Biomédicales". Collection Rencontres en Toxinologie SFET, Elsevier, ISBN: 2-84299-445-0, Nov. 2002,  pp. 203-204.